DNA adduct and mutational profiles reveal a threshold of cellular defenses against N-nitrosodimethylamine administered to mice in drinking water
N. E. Gubina, L. B. Volk, A. F. Dormitzer, E. M. Michelsen, L. J. Pribyl, J. J. Corrigan, E. D. Dalvie, A. L. Armijo, M. M. Norales, N. A. Bugher, K. M. Schonvisky, D. L. Plata, B. P. Engelward, R. G. Croy, J. M. Essigmann, B. I. Fedeles
This study examines DNA adducts and mutations in mice exposed to NDMA, finding that m6G adducts and mutations increase beyond a certain dose threshold, implicating MGMT saturation in mutagenesis.
bioRxiv · Nov 13, 2025 · PreprintPharmacology & Toxicology