Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
J. E. Kay, J. J. Corrigan, A. L. Armijo, I. S. Nazari, I. N. Kohale, D. K. Torous, S. L. Avlasevich, R. G. Croy, D. N. Wadduwage, S. E. Carrasco, S. D. Dertinger, F. M. White, J. M. Essigmann, L. D. Samson, B. P. Engelward
The paper shows that altering AAG levels in mice changes the outcome of NDMA exposure from cancer to lethality by shifting the balance between replication-blocking lesions and strand breaks.
bioRxiv · Jan 12, 2021Cancer Biology