1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer
M. K. Kilgour, S. MacPherson, L. Zacharias, S. Keyes, B. Pauly, B. Allard, J. Smazynski, P. H. Watson, J. Stagg, B. H. Nelson, R. J. DeBerardinis, P. T. Hamilton, J. J. Lum
This study identifies 1-methylnicotinamide (MNA) as an immune regulatory metabolite in high-grade serous ovarian cancer, showing its role in modulating T cell function through non-cell autonomous mechanisms.
bioRxiv · May 5, 2020Immunology