Author

J. Stagg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:metabolomics· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Allard· 2 shared Y. Bareche· 2 shared A.-M. Mes-Masson· 1 shared B. Cormier· 1 shared B. H. Nelson· 1 shared B. Pauly· 1 shared C. Zhao· 1 shared D. Allard· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

B. Allard

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The CD73 immune checkpoint promotes tumor cell metabolic fitness

D. Allard, I. Cousineau, E. H. Ma, B. Allard, Y. Bareche, H. Fleury, J. Stagg

This study identifies CD73 as a metabolic regulator in tumor cells, showing it enhances mitochondrial respiration and aspartate biosynthesis, and that targeting CD73 reduces metabolic fitness and genomic stability.

eLife · Jun 1, 2023Peer-reviewedCancer Biology

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer

M. dos Santos Carneiro, Y. Bareche, C. Zhao, P. Thebault, K. Rahimi, D. Provenche, V. Samouelian, B. Cormier, J.-F. Cailhier, A.-M. Mes-Masson, S. Petropoulos, J. Stagg, R. Lapointe

The paper identifies developmental relationships between tumor and circulating T cells in ovarian cancer using single-cell transcriptomics and TCR analysis, revealing a differentiation pathway and interactions with Tfh-like cells.

bioRxiv · Feb 28, 2023 · PreprintImmunology

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

M. K. Kilgour, S. MacPherson, L. Zacharias, S. Keyes, B. Pauly, B. Allard, J. Smazynski, P. H. Watson, J. Stagg, B. H. Nelson, R. J. DeBerardinis, P. T. Hamilton, J. J. Lum

This study identifies 1-methylnicotinamide (MNA) as an immune regulatory metabolite in high-grade serous ovarian cancer, showing its role in modulating T cell function through non-cell autonomous mechanisms.

bioRxiv · May 5, 2020Immunology

Immunotherapy efficacy in colorectal cancer is dependent on activation of a microbial-metabolite-immune circuit

L. Mager, R. Burkhard, N. Cooke, K. Brown, H. Ramay, S. Paik, J. Stagg, R. Grooves, M. Gallo, I. Lewis, M. Geuking, K. McCoy

This study identifies specific gut bacteria and the metabolite inosine that enhance immunotherapy efficacy in colorectal cancer by promoting Th1 cell activation through the adenosine A2A receptor.

bioRxiv · Feb 26, 2020 · PreprintCancer Biology