Role of vaccinia virus growth factor in stimulating the mTORC1-CAD axis of the de novo pyrimidine pathway under different nutritional cues
L. Dsouza, A. Pant, B. Pope, Z. Yang
This study identifies vaccinia virus growth factor (VGF) as a key factor enabling mTORC1-CAD axis activation in nutrient-poor conditions, enhancing de novo pyrimidine synthesis for viral replication.
bioRxiv · Jul 2, 2024Microbiology