A. Pant

Biomolecular condensates are characterized by interphase electric potentials

The paper shows that biomolecular condensates generate interphase electric potentials due to ion asymmetry, suggesting they function as mesoscale capacitors.

Role of vaccinia virus growth factor in stimulating the mTORC1-CAD axis of the de novo pyrimidine pathway under different nutritional cues

This study identifies vaccinia virus growth factor (VGF) as a key factor enabling mTORC1-CAD axis activation in nutrient-poor conditions, enhancing de novo pyrimidine synthesis for viral replication.

Nrf2 regulates the activation-driven expansion of CD4+ T-cells by differentially modulating glucose and glutamine metabolism

This study shows Nrf2 modulates CD4+ T-cell activation and expansion by altering glucose and glutamine metabolism, offering insights for improving immunotherapies.

Upregulation of ATP Citrate Lyase Phosphorylation and Neutral Lipid Synthesis through Viral Growth Factor Signaling during Vaccinia Virus Infection

This study shows that Vaccinia virus increases ACLY phosphorylation via VGF-EGFR-Akt signaling, enhancing lipid synthesis and viral replication.

Antiviral activities of two nucleos(t)ide analogs against vaccinia and mpox viruses in primary human fibroblasts

This study evaluates the antiviral effects of two nucleos(t)ide analogs against vaccinia and mpox viruses in human fibroblasts, finding potent inhibition with low EC50 values and validating a new reporter tool for inhibitor screening.

CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure

This study shows that excessive IL-6 in acetaminophen-induced liver failure causes immune suppression, reduced cerebral blood flow, and increased mortality in mice.

The endophilin curvature-sensitive motif requires electrostatic guidance to recycle synaptic vesicles in vivo

This study shows that endophilin's curvature-sensitive motif requires electrostatic guidance for synaptic vesicle recycling, and that altering this property can restore function in non-functional chimeras.

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.

Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell line

This study shows that TM6SF2 overexpression or loss-of-function alters lipid metabolism in human liver cells by changing lipid species composition and gene expression.

Asparagine availability is an essential limiting factor for poxvirus protein synthesis

This study shows that asparagine availability is critical for poxvirus replication and protein synthesis, challenging the notion that glutamine is superior to glucose for viral replication.