Author

B. R. Wilde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. E. Ayer· 2 shared B. Shuch· 1 shared D. Ueno· 1 shared E. D. Esplin· 1 shared H. R. Christofk· 1 shared J. Gertz· 1 shared J. M. Vahrenkamp· 1 shared K. E. Murphy· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

D. E. Ayer

Mutual co-authors in cluster

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3 papers

Recent·Most cited

FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer

B. R. Wilde, N. Chakraborty, N. Matulionis, S. Hernandez, D. Ueno, M. E. Gee, E. D. Esplin, K. Ouyang, K. Nykamp, B. Shuch, H. R. Christofk

This paper functionally characterizes FH variants of uncertain significance and identifies purine salvage pathway dependence as a targetable vulnerability in FH-deficient kidney cancer.

bioRxiv · Aug 15, 2022Cancer Biology

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

T.-Y. Lim, B. R. Wilde, M. L. Thomas, K. E. Murphy, J. M. Vahrenkamp, M. E. Conway, K. E. Varley, J. Gertz, D. E. Ayer

This study shows that TXNIP loss increases Myc genomic binding, expanding Myc-dependent transcriptional programs without increasing Myc levels or activity.

bioRxiv · Aug 4, 2022 · PreprintCancer Biology

Cellular acidosis triggers MondoA transcriptional activity by driving mitochondrial ATP production

D. E. Ayer, B. R. Wilde, Z. Ye

The paper shows acidosis activates MondoA by increasing mitochondrial ATP production, which leads to G6P synthesis and nuclear MondoA translocation.

bioRxiv · Jul 24, 2018Cancer Biology