H. R. Christofk

The paper maps fetal metabolism during mid-to-late gestation in normal and diabetic pregnancies, identifying metabolic changes due to maternal hyperglycemia.

This paper functionally characterizes FH variants of uncertain significance and identifies purine salvage pathway dependence as a targetable vulnerability in FH-deficient kidney cancer.

This study shows that inhibiting MCT1 and MCT4 in EBV-driven lymphomas disrupts metabolism, leading to growth arrest and sensitization to metformin, revealing a potential therapeutic strategy.

This study shows that asparagine, derived from mitochondrial respiration, supports mTORC1 activity and tumor growth, and that targeting asparagine synthesis or consumption can impair tumor growth.