Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma
E. J. P. Tokarsky, J. C. Crow, L. M. Guenther, J. Sherman, C. Taslim, G. Alexe, K. I. Pishas, G. Rask, B. S. Justis, A. Kasumova, K. Stegmaier, S. L. Lessnick, E. R. Theisen
The paper identifies mitochondrial dysfunction as a mechanism of resistance to the LSD1 inhibitor SP-2509 in Ewing sarcoma and suggests combining LSD1 inhibitors with mitochondrial-targeting agents.
bioRxiv · Dec 13, 2021Cancer Biology