Author

L. M. Guenther

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

K. Stegmaier· 2 shared A. Iniguez· 1 shared A. Kasumova· 1 shared B. S. Justis· 1 shared C. Taslim· 1 shared D. Chowdhury· 1 shared E. J. P. Tokarsky· 1 shared E. R. Theisen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

K. Stegmaier

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2 papers

Recent·Most cited

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

V. Rendo, M. Schubert, N. Khuu, M. F. Suarez Peredo Rodriguez, K. Huang, M. Swift, Y. He, J. Zerbib, R. Smith, J. Raaijmakers, P. Bandopadhayay, L. M. Guenther, J. H. Hwang, A. Iniguez, S. Moody, , F. Foijer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

bioRxiv · Dec 16, 2023 · PreprintCancer Biology

Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma

E. J. P. Tokarsky, J. C. Crow, L. M. Guenther, J. Sherman, C. Taslim, G. Alexe, K. I. Pishas, G. Rask, B. S. Justis, A. Kasumova, K. Stegmaier, S. L. Lessnick, E. R. Theisen

The paper identifies mitochondrial dysfunction as a mechanism of resistance to the LSD1 inhibitor SP-2509 in Ewing sarcoma and suggests combining LSD1 inhibitors with mitochondrial-targeting agents.

bioRxiv · Dec 13, 2021Cancer Biology