Cystic fibrosis transmembrane conductance regulator (CFTR) inhibition results in mucus accumulation in human airway epithelia Calu-3 cells: Experimental and Machine Learning Studies
B. S. Laethem, K. T. Lewis, R. Ramos, X. Hou, F. Sun, D. J. Taatjes, B. P. Jena, S. Arslanturk
This study uses electron microscopy and machine learning to show that CFTR inhibition reduces secretory vesicle swelling and mucin release in Calu-3 cells, leading to mucus accumulation.
bioRxiv · May 26, 2020 · PreprintCell Biology