SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells
L. P. Swift, B. C. Lagerholm, H. T. Baddock, L. R. Henderson, M. Ratnaweera, B. Sengerova, S. Y. Lee, A. Cruz-Migoni, D. Waithe, C. Renz, H. D. Ulrich, J. A. Newman, C. J. schofield, P. J. McHugh
This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.
bioRxiv · Jul 21, 2022 · PreprintBiochemistry