Author

B. C. Lagerholm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:Drosophila· 1

Frequent Co-Authors

E. Sezgin· 3 shared C. Eggeling· 2 shared D. Shrestha· 2 shared J. A. Newman· 2 shared A. A. Carr· 1 shared A. Cruz-Migoni· 1 shared A. E. Handel· 1 shared A. E. Lindsay· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

E. Sezgin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

L. P. Swift, B. C. Lagerholm, H. T. Baddock, L. R. Henderson, M. Ratnaweera, B. Sengerova, S. Y. Lee, A. Cruz-Migoni, D. Waithe, C. Renz, H. D. Ulrich, J. A. Newman, C. J. schofield, P. J. McHugh

This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL

T. L. Steinacker, S.-S. Wong, Z. A. Novak, S. Saurya, L. Gartenmann, E. J. H. van Houtum, J. R. Sayers, B. C. Lagerholm, J. W. Raff

The paper shows that centriole growth in Drosophila embryos is not limited by component availability but by Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL, which regulates growth timing.

bioRxiv · Feb 15, 2022Cell Biology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy

F. Schneider, P. Hernandez-Varas, B. C. Lagerholm, D. Shrestha, E. Sezgin, J. Roberti, G. Ossato, F. Hecht, C. Eggeling, I. Urbancic

This paper demonstrates that high photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy by using advanced detection equipment.

Journal of Physics D: Applied Physics · Feb 13, 2020Peer-reviewedBiophysics

A cell-topography based mechanism for ligand discrimination by the T-cell receptor

R. A. Fernandes, K. A. Ganzinger, J. Tzou, P. Jonsson, S. F. Lee, M. Palayret, A. M. Santos, A. A. Carr, A. Ponjavic, V. T. Chang, C. Macleod, B. C. Lagerholm, A. E. Lindsay, O. Dushek, A. Tilevik, , D. Klenerman

This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.

Proceedings of the National Academy of Sciences · Jun 20, 2019Peer-reviewedImmunology

Complementary studies of lipid membrane dynamics using iSCAT and super-resolved Fluorescence Correlation Spectroscopy

F. Reina, S. Galiani, D. Shrestha, E. Sezgin, G. de Wit, D. Cole, B. C. Lagerholm, P. Kukura, C. Eggeling

This paper compares STED-FCS and iSCAT techniques for measuring lipid diffusion on SLBs using hybrid fluorescent-gold nanoparticle tags, finding significant differences in diffusion coefficients.

bioRxiv · Apr 13, 2018Biophysics