Author

P. J. McHugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

C. J. schofield· 3 shared H. T. Baddock· 3 shared A. Cruz-Migoni· 2 shared J. A. Newman· 2 shared M. Bielinski· 2 shared M. Ratnaweera· 2 shared Y. Yosaatmadja· 2 shared A. A. Dannerfjord· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

C. J. schofield

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Author profile →

3 papers

Recent·Most cited

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

L. P. Swift, B. C. Lagerholm, H. T. Baddock, L. R. Henderson, M. Ratnaweera, B. Sengerova, S. Y. Lee, A. Cruz-Migoni, D. Waithe, C. Renz, H. D. Ulrich, J. A. Newman, C. J. schofield, P. J. McHugh

This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Y. Yosaatmadja, H. T. Baddock, J. A. Newman, M. Bielinski, A. E. Gavard, S. M. M. Mukhopadhyay, A. A. Dannerfjord, C. J. Schofield, P. J. McHugh, O. Gileadi

This study presents crystal structures of Artemis variants and identifies a unique metal binding site, providing insights for inhibitor development.

bioRxiv · Jan 8, 2021Biochemistry

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

H. T. Baddock, S. Brolih, Y. Yosaatmadja, M. Ratnaweera, M. Bielinski, L. Swift, A. Cruz-Migoni, G. M. Morris, C. J. Schofield, O. Gileadi, P. J. McHugh

This study characterizes the SARS-CoV-2 nsp14-nsp10 complex as an RNA nuclease, identifies its role in genome stability, and discovers inhibitors targeting this complex.

bioRxiv · Aug 13, 2020 · PreprintBiochemistry