Author

J. A. Newman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Ecology· 4 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Research Focus:ecology & biodiversity· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein structure prediction· 3 Approach:statistical model· 3 Assay:structural biology· 3

Frequent Co-Authors

O. GileadiiD· 5 shared A. E. Gavard· 2 shared A. E. Handel· 2 shared B. C. Lagerholm· 2 shared C. J. schofield· 2 shared G. A. Hollander· 2 shared H. A. Hager· 2 shared H. T. Baddock· 2 shared

Activity by Year

2018-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersBiochemistry

O. GileadiORCID

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11 papers

Recent·Most cited

Geographic variation in evolutionary rescue in a predator-prey system under climate change: an example with aphids and ladybird beetles

X. Ge, J. A. Newman, C. Griswold

The paper develops an eco-evolutionary model to study geographic variation in evolutionary rescue in a predator-prey system under climate change, finding that ladybirds are more likely to be rescued in southeastern locations.

bioRxiv · Mar 21, 2023Evolutionary Biology

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

L. P. Swift, B. C. Lagerholm, H. T. Baddock, L. R. Henderson, M. Ratnaweera, B. Sengerova, S. Y. Lee, A. Cruz-Migoni, D. Waithe, C. Renz, H. D. Ulrich, J. A. Newman, C. J. schofield, P. J. McHugh

This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

Predator-prey interactions in a warming world: the critical role of cold tolerance

X. Ge, C. K. Griswold, J. A. Newman

This study examines how predator-prey interactions respond to climate change by analyzing thermal tolerance mismatches in ladybird beetles and aphids.

bioRxiv · Jan 17, 2022Ecology

Allelopathic effects of Epichloë fungal endophytes: experiment and meta-analysis

H. A. Hager, M. Gailis, J. A. Newman

The paper tests if Epichloe fungal endophytes have allelopathic effects on neighboring plants through experiments and meta-analysis, finding little evidence of negative effects.

bioRxiv · Nov 10, 2021Ecology

Structure, Mechanism and Crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

J. A. Newman, A. Douangamath, S. Yazdani, Y. Yosaatmadja, A. Aimon, J. Brandao-Neto, L. Dunnett, T. Gorrie-Stone, R. Skyner, D. Fearon, M. Schapira, F. von Delft, O. Gileadi

This study presents crystal structures of SARS-CoV-2 NSP13 and identifies druggable pockets, revealing potential targets for antiviral drug development through fragment screening.

Nature Communications · Aug 11, 2021Peer-reviewedBiochemistry

Climate change and the complex dynamics of green spruce aphid--spruce plantation interactions

J. H. M. Thornley, J. A. Newman

The paper develops a mathematical model to study green spruce aphid dynamics and their impact on spruce plantations under climate change, finding complex population patterns and climate variable effects on yield.

bioRxiv · May 26, 2021Ecology

Costs, Benefits, Parasites and Mutualists: The Use and Abuse of the Mutualism-Parasitism Continuum Concept for Epichloë Fungi

J. A. Newman, S. Gillis, H. A. Hager

The paper argues that strictly vertically transmitted Epichloë fungi should not be classified as parasites or fit on a mutualism-parasitism continuum, using a mathematical model to clarify the requirements for parasitism.

bioRxiv · Apr 21, 2021Ecology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Y. Yosaatmadja, H. T. Baddock, J. A. Newman, M. Bielinski, A. E. Gavard, S. M. M. Mukhopadhyay, A. A. Dannerfjord, C. J. Schofield, P. J. McHugh, O. Gileadi

This study presents crystal structures of Artemis variants and identifies a unique metal binding site, providing insights for inhibitor development.

bioRxiv · Jan 8, 2021Biochemistry

Crystal Structure of the Werner's Syndrome Helicase

J. A. Newman, A. E. Gavard, S. Lieb, M. C. Ravichandran, K. Hauer, P. Werni, L. Geist, J. Boettcher, J. R. Engen, K. Rumpel, M. Samwer, M. Petronczki, O. Gileadi

This study determines the crystal structure of the WRN helicase core and identifies structural features that may aid in designing inhibitors against WRN helicase.

bioRxiv · May 4, 2020 · PreprintBiochemistry

The structural basis for forkhead box family specificity revealed by the crystal structure of human FOXN1 in complex with DNA

J. A. Newman, H. Aitkenhead, A. Gavard, I. A. Rota, A. E. Handel, G. A. Hollander, O. Gileadi

This paper presents the crystal structure of human FOXN1 bound to DNA, revealing structural basis for its specificity and reduced affinity for methylated DNA.

bioRxiv · Sep 26, 2018Biochemistry