Peptide Avidity for TCR on CD4 Effectors Determines the Extent of Memory Generation
M. C. Jones, C. Castonguay, P. P. Nanaware, G. C. Weaver, B. Stadinski, O. A. Kugler-Umana, E. Huseby, L. J. Stern, P. J. Devarajan, S. L. Swain
This study shows that higher peptide antigen avidity for TCR on CD4 effector cells leads to increased memory cell generation and better protection against influenza rechallenge.
bioRxiv · May 9, 2022Immunology