Receptor-guided engineering of oncolytic vaccinia creates a synthetic support niche for off-the-shelf NK cell therapy
R. Rezaei, Z. Gan, N. Akeem Akilimali, J. Reff, M. Lin, Y. Xiao, K. Parikh, D. Vithlani, B. Valentic, A. A. Shestov, U. Uslu, T. Azad, R. S. OConnor, C. H. June, Neil C. Sheppard
This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.
bioRxiv · Nov 9, 2026 · PreprintBioengineering