Z. Gan

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS

This study demonstrates that a novel siRNA modality, conjugated with an accessory oligonucleotide, improves survival and motor function in a mouse model of ALS when delivered locally to the CNS.

Curvature of the retroviral capsid assembly is modulated by a molecular switch

The paper identifies key residues that enable a molecular switch in retroviral capsid proteins, allowing curvature changes during capsid assembly.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Decoupling global biases and local interactions between cell biological variables

The paper introduces DeBias, a method to separate global biases from local interactions in cell biology data, showing global bias contains mechanistic insights.