A risk-reward tradeoff of high ribosome production in proliferating cells
B. W. Tye, N. Commins, M. Springer, D. Pincus, L. S. Churchman
The paper shows that disruptions in ribosome biogenesis in yeast cause proteostasis loss, and enhancing proteostasis improves cell fitness under ribosome assembly stress.
bioRxiv · Oct 31, 2018Cell Biology