L. S. Churchman

The paper quantifies differences in nuclear and mitochondrial gene expression kinetics and identifies regulatory mechanisms underlying OXPHOS biogenesis.

The paper investigates how human cells balance mitochondrial and cytosolic translatomes to coordinate OXPHOS complex biogenesis and maintains proteostasis through LRPPRC.

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

The paper shows that disruptions in ribosome biogenesis in yeast cause proteostasis loss, and enhancing proteostasis improves cell fitness under ribosome assembly stress.