Depletion of tropomyosin 1.6 promotes matrix-degrading phenotype in TGF-β1-induced myofibroblast
C. L. Wu, G.-H. Lee, B. Y. Chen, C.-H. Kuo, T. T. Chan, Y.-K. Wang, T. Y. Wong, M.-J. Tang
This study shows that Tpm1.6 depletion reduces TGF-β1-induced myofibroblast contractility and enhances collagen degradation, suggesting it as a therapeutic target for fibrosis.
bioRxiv · Dec 8, 2023 · PreprintCell Biology