T. Y. Wong

This study shows that Tpm1.6 depletion reduces TGF-β1-induced myofibroblast contractility and enhances collagen degradation, suggesting it as a therapeutic target for fibrosis.

This study shows an intranasal VLP-RBD vaccine with BECC470 adjuvant provides protection against Delta SARS-CoV-2 in mice, with mucosal immunity and reduced lung inflammation.

This study compares the pathogenesis of SARS-CoV-2 Delta and Alpha variants in K18-hACE2 mice, finding Delta causes more inflammation, tissue damage, and interferon responses.

This study shows that mucosal vaccination with aP protects against Bp infection and cough in rats, inducing mucosal immunity and reducing bacterial burden.

This study compares the pathogenicity and immune response of SARS-CoV-2 variants B.1.1.7 and B.1.351 with WA-1 in mice, showing reduced protection from convalescent plasma against the variants.

This study uses a rat model to compare disease manifestations between two genetically distinct Bordetella pertussis strains, finding that D420 induces more severe coughing and immune responses than Tohama 1.

This study uses in vivo imaging and transcriptomic analysis to compare immune responses in mice vaccinated against B. pertussis, finding differential gene expression and neutrophil dynamics across vaccine types.