BRD4 binds the nucleosome via both histone and DNA interactions
Jiang Zhu, Erik M. Leith, Erin N. O’Donnell, B.P. Manzano, Shwu-Yuan Wu, Cheng‐Ming Chiang, Jean‐Paul Armache, Song Tan
This study reveals how BRD4 binds nucleosomes through both histone and DNA interactions, showing that acetylation of H4 influences the BRD4/nucleosome complex conformation.
Molecular Cell · Aug 1, 2026Peer-reviewedMolecular Biology