Jean‐Paul Armache

This study isolates and structures native Pol II transcription complexes and nucleosomes from Drosophila embryos, revealing new insights into transcription dynamics and nucleosome interactions.

This study reveals how BRD4 binds nucleosomes through both histone and DNA interactions, showing that acetylation of H4 influences the BRD4/nucleosome complex conformation.

The paper shows that different binding modes to the nucleosome acidic patch lead to distinct cellular outcomes, with overexpression of Dot5 and camelid antibodies causing growth, DNA repair, and heterochromatin defects.