Author
Harold C. Simmons Comprehensive Cancer CenterORCID 0009-0000-9088-4724Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Jiang Zhu, Erik M. Leith, Erin N. O’Donnell…·Song Tan
This study reveals how BRD4 binds nucleosomes through both histone and DNA interactions, showing that acetylation of H4 influences the BRD4/nucleosome complex conformation.
Nathaniel T. Burkholder, Shwu-Yuan Wu, Jackson Handy…·Brian D. Strahl
This study shows that BRD4's tandem bromodomains cooperatively bind poly-acetylated nucleosomes, enhancing chromatin engagement and influencing breast cancer phenotypes.
Naveen Sanath Kumar, Zonghui Ma, Fuquan Long…·Hu Haitao
This study identifies ZL0580 as a BRD4-targeting small molecule that suppresses HIV in vivo through epigenetic mechanisms, showing potent antiviral effects in a humanized mouse model.