Spatiotemporal proteomics reveals dynamic antagonistic gradients shaping signalling waves
Wilke H. M. Meijer, Virginia Andrade, Suzan Stelloo, Wouter M. Thomas, Marek J. van Oostrom, Balaji Srinivasan, Dimitri Fabrèges, Sita Venkataraman, Sonja D. C. Weterings, Jan-Daniël de Leede-Scheven, Eveline F. Ilcken, Kim T. J. Peters, Michiel Vermeulen, Katharina F. Sonnen
The paper uses a microfluidics and proteomics approach to study dynamic protein gradients in mouse embryos, revealing antagonistic ligand-receptor patterns that regulate Wnt oscillations and somite formation.
Nature Communications · Oct 25, 2026Peer-reviewedDevelopmental Biology