Katharina F. Sonnen

Spatiotemporal proteomics reveals dynamic antagonistic gradients shaping signalling waves

The paper uses a microfluidics and proteomics approach to study dynamic protein gradients in mouse embryos, revealing antagonistic ligand-receptor patterns that regulate Wnt oscillations and somite formation.

NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis

The paper shows that NOTCH-driven Hes1 oscillations with different periods control cell fate decisions in intestinal stem cells, influencing secretory and absorptive lineage commitment.

Human embryo implantation involves Syncytin-2/MFSD2A-mediated heterokaryon formation with maternal endometrium

The paper shows that human embryo implantation involves Syncytin-2/MFSD2A-mediated cell fusion between blastoids and endometrial epithelial cells, preventing implantation when MFSD2A is knocked out.

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids

This study shows that a NOTCH1 mutation affects NICD stability and disrupts segmentation clock function in hiPSC-derived PSM cells and somitoids.

Coupling of cell proliferation to the segmentation clock ensures robust somite scaling

The paper shows that coupling cell proliferation to the segmentation clock ensures uniform PSM growth and precise somite scaling in mouse embryos.

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking

This study uses single-cell tracking to analyze Hes1 dynamics in mouse embryos, revealing distinct oscillation patterns in presomitic mesoderm and preneural tube cells.

Arnold tongue entrainment reveals dynamicalprinciples of the embryonic segmentation clock

The paper uses a coarse-grained theoretical-experimental approach to study the dynamics of the mouse embryonic segmentation clock, revealing its non-linear oscillator characteristics and long-term feedbacks.