Yaniv Erlich

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

The paper describes a scalable pipeline for constructing SARS-CoV-2 replicons using de-novo synthesis, demonstrating their safety and utility for drug testing.

This study shows that low coverage sequencing can effectively match relatives with genotyping arrays, achieving similar accuracy for close relatives and strong correlation for distant ones.

The paper introduces Sci-LMM, a framework for analyzing population-scale family trees, and estimates heritability of longevity and reproductive fitness in a large historical pedigree.

FactorialHMM provides fast exact inference for factorial hidden Markov models, enabling efficient state sequence and likelihood computation with linearithmic time and space complexity.

This study investigates the ability to re-identify individuals through long-range familial searches in consumer genomics databases, finding that half of European-descent searches could yield close matches enabling re-identification.

The paper creates a population-scale family tree resource using crowd-sourced genealogy data to study genetic architecture and family dispersion.

DNA.Land collects genomes and phenomes at scale using crowdsourcing from DTC companies, achieving 43,000 genomes in 20 months with reduced resources.

The paper estimates mutation parameters for human STRs by correlating genotypes with sequence heterozygosity and uses constraint scores to identify pathogenic variants.

The paper critiques Lippert et al.'s method for re-identifying individuals from whole-genome sequencing data, highlighting its flaws in performance, methodology, and conclusions.

The paper describes a DNA-based storage system called DNA Fountain that efficiently stores and retrieves digital data with high robustness and density.

DNA Compass provides a secure, client-side website for navigating personal genomic data, allowing users to query variant status for 400+ conditions and millions of SNPs without leaving their computer.

This study introduces HipSTR, a haplotype-based method for genotyping STRs and reports genome-wide analysis of de novo STR mutations.

The paper identifies 2,060 expression STRs (eSTRs) contributing 10%-15% of cis-heritability to gene expression, highlighting their role as regulatory variants.

The paper introduces mathematical frameworks and tools for efficient combinatorial pooling designs in biological screens using linear codes, reducing waste and improving flexibility.

The paper describes integrating handheld DNA sequencers into an academic classroom to provide hands-on training in DNA sequencing technologies.

The paper analyzes human STR variation across 1,000 genomes, identifies common loss-of-function alleles, and estimates linkage disequilibrium with SNPs.

The paper identifies a 1.3Mb duplication on chromosome 14q22.3 in HFM patients, implicating OTX2 dosage sensitivity in craniofacial development and linking it to medulloblastoma.