Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies
Raphaël Jeger-Madiot, Delphine Planas, Isabelle Staropoli, Jérôme Kervevan, Héloïse Mary, Camilla Collina, Barbara F. Fonseca, Hippolyte Debarnot, Rémy Robinot, Stacy Gellenoncourt, Olivier Schwartz, Lorna Ewart, Michael Bscheider, Samy Gobaa, Lisa A. Chakrabarti
The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.
bioRxiv · Feb 2, 2024 · PreprintImmunology