Lisa A. Chakrabarti

Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature

This study shows that the SARS-CoV-2 Omicron variant replicates more efficiently and evades innate immune responses in a nasal epithelium model at physiological temperature.

Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.

Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants

The paper shows SARS-CoV-2 variants reduce m6A RNA methylation in host cells, affect METTL3 localization, and impair stress granules, with XPO1 inhibition reversing some effects.