Olivier Schwartz

Epitope-Driven Polyfunctional Divergence of SARS-CoV-2 RBD Antibodies

This study examines how SARS-CoV-2 RBD antibodies differ in function, showing that neutralizing antibodies lose effectiveness against variants but retain effector functions, while non-neutralizers remain broadly reactive but less effective overall.

SARS-CoV-2 ORF9b exploits mitochondrial recruitment to TOMM70 for proteasomal protection and tunes inflammatory remodeling during lung infection

This study shows SARS-CoV-2 ORF9b uses TOMM70 to avoid proteasomal degradation, reduces inflammation, and is not essential for viral replication or lung pathology.

Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1

This study shows human coronavirus HKU1 replicates more efficiently at nasal temperature (33°C) than at body temperature (37°C), with differences in innate immune response and viral stability.

Variant-specific spike conformational dynamics shape memory B cell selection during recall

The paper shows that variant-specific spike conformational dynamics influence memory B cell recruitment and antibody responses during vaccination.

Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells

This study investigates BANAL-236, a SARS-CoV-2-related bat virus, showing it can use human entry factors and evade human innate immunity, suggesting potential for zoonotic spillover.

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike

This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.

Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature

This study shows that the SARS-CoV-2 Omicron variant replicates more efficiently and evades innate immune responses in a nasal epithelium model at physiological temperature.

Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153

The paper identifies OPG153 as a target of broadly neutralizing antibodies against MPXV and related viruses using antigen-agnostic isolation, AlphaFold 3 modeling, and cryo-EM.

Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein

The paper develops a pipeline to generate potent Affitins targeting SARS-CoV-2 spike protein RBD, achieving high neutralization potency with IC50 values as low as 0.8 pM.

Potent Neutralization by Antibodies Targeting the Mpox A28 Protein

The paper identifies and characterizes monoclonal antibodies targeting the Mpox A28 protein, showing potent neutralization of Mpox and Vaccinia virus through complement-dependent mechanisms and providing protection in mice.

Antiviral activity of Tecovirimat against Mpox virus clades 1a, 1b, 2a and 2b

This study evaluates Tecovirimat's antiviral activity against four Mpox virus clades and finds it effectively inhibits all at nanomolar concentrations.

SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts

This study shows that SARS-CoV-2 entry and fusion depend on cholesterol but not on ACE2 localization to lipid rafts.

HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1

This study shows that HIV-1 budding requires MICAL1-mediated actin disassembly at the plasma membrane, with Rab35 also playing a role in this process.

Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

Escape of SARS-CoV-2 variants KP1.1, LB.1 and KP3.3 from approved monoclonal antibodies

The paper evaluates the neutralization activity of two new monoclonal antibodies against emerging SARS-CoV-2 variants and finds reduced efficacy against some sublineages.

B cell maturation restored ancestral germlines to control Omicron BA.2.86

The paper analyzes neutralizing antibodies from vaccinated and hybrid immune individuals to show that restored B cell germlines enhance neutralization against SARS-CoV-2 variants like BA.2.86.

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

The paper identifies environmental and genetic factors influencing population differences in SARS-CoV-2 immune responses using single-cell RNA-sequencing data.

The Immune Factors Driving DNA Methylation Variation in Human Blood

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2

This study shows that iPSC-derived neural progenitors and glutamatergic neurons are not permissive to SARS-CoV-2 infection unless ACE2 is overexpressed.

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus

The paper shows that extracellular vesicles with ACE2 can block SARS-CoV-2 infection more effectively than soluble ACE2.