The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau
Stefanie-Elisabeth Heumüller, Mikhail E. Sushkin, Elisa Sánchez-Sendín, André Hossinger, Dominik Stappert, Nazlican Altinisik, Louisa Seiwert, Lydia Paulsen, Adalbert Krawczyk, Barbara G. Klupp, Thomas C. Mettenleiter, Philip Denner, Harald Prüß, Ina Maja Vorberg
This study shows HSV-1 fusion proteins enable cell-to-cell spread of pathological Tau, suggesting latent HSV-1 infection may contribute to neurodegenerative disease progression.
bioRxiv · Jan 21, 2026 · PreprintNeuroscience