Harald Prüß

Anti-GABAB receptor autoimmunity causes cognitive decline by presynaptic pathology

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

Entropy of the resting state cortex in epilepsy

This study finds that recurrent seizures in epilepsy are associated with reduced cortical entropy in the interictal state, particularly in those with earlier seizure onset.

Spatial navigation impairment beyond episodic memory in autoimmune encephalitis

This study investigates spatial navigation impairment in post-acute NMDAR and LGI1 encephalitis, finding it common and partially dissociable from episodic memory dysfunction.

AMPAR immunization induces progressive autoimmune encephalitis with autoreactive B cells in the brain

This study develops a mouse model of anti-AMPAR encephalitis and shows that autoreactive B cells and plasma cells accumulate in the brain, driving disease progression.

The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity

This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.

Anti-NMDAR encephalitis alters intrinsic spatiotemporal coding by enhancing neuronal coupling and clustering

This study investigates how anti-NMDAR encephalitis alters neuronal network function by enhancing coupling and clustering in hippocampal neurons during slow-wave sleep.

A High-Throughput Automated Pipeline to Analyze Synapse Function by Calcium Imaging

This paper introduces a high-throughput automated pipeline for analyzing synaptic function via calcium imaging and demonstrates its sensitivity in detecting synaptic dysfunction.

The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau

This study shows HSV-1 fusion proteins enable cell-to-cell spread of pathological Tau, suggesting latent HSV-1 infection may contribute to neurodegenerative disease progression.

Functional connectivity is linked to symbolic BOLD patterns: replication, extension, and clinical application of the human 'complexome'

The paper replicates and extends the complexome framework by linking functional connectivity to symbolic BOLD patterns, showing clinical relevance in anti-NMDA receptor encephalitis and introducing a new measure of pattern dissimilarity.

Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

The paper examines four new anti-Caspr2 antibodies, showing they target different epitopes and induce varying ASD-like phenotypes in male mice offspring.

Memory dysfunction and psychiatric outcomes in anti-NMDA receptor encephalitis are linked to altered structural brain complexity

This study links altered structural brain complexity in post-acute anti-NMDA receptor encephalitis to memory dysfunction and psychiatric outcomes using fractal dimensionality analysis.

Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability

The paper investigates how CASPR2 autoantibody subclasses, particularly IgG4, affect neuronal excitability and potassium channel function in patients with neuropathic pain.

Hippocampal hub failure is linked to long-term memory impairment in anti-NMDA-receptor encephalitis -Insights from structural connectome graph theoretical network analysis

This study uses graph theoretical analysis of structural brain networks to show that hippocampal hub failure in NMDAR encephalitis is linked to long-term memory impairment.

It only takes seconds for a human monoclonal autoantibody to inhibit N-methyl-D-aspartate receptors

This study shows a patient-derived monoclonal antibody rapidly inhibits N-methyl-D-aspartate receptors directly, suggesting potential therapeutic strategies using antigen-binding fragments.

Persistent cognitive deficits in anti-LGI1 encephalitis are linked to a reorganization of structural brain networks

This study links persistent cognitive deficits in anti-LGI1 encephalitis to structural brain network reorganization despite immunotherapy and clinical recovery.

Maternofetal transfer of human NMDAR-antibodies leads to cortical network defect in adolescence

This study shows that maternal-fetal transfer of NMDAR-antibodies causes lasting impairments in adolescent brain network function and connectivity.

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

NMDA-receptor-Fc-fusion constructs neutralize anti- NMDA receptor antibodies

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.

Reduced resilience of brain state transitions in patients with anti-N-Methyl-D-Aspartate receptor encephalitis

The paper examines brain state transitions in anti-NMDA receptor encephalitis patients, finding reduced network stability and resilience linked to disease severity.

Glaucoma and Alzheimer: Neurodegenerative disorders show an adrenergic dysbalance

This study investigates autoimmune phenomena targeting the β2-AR in Alzheimer's Disease patients, finding that long-chain Aβ peptides activate the β2-AR and that AD patients have functional autoantibodies similar to those in glaucoma.

Insights into standards of care: dexamethasone and antibodies against COVID-19 in hamster models

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.

Impaired functional connectivity of the hippocampus in murine models of NMDA-receptor antibody associated pathology

This study investigates functional connectivity changes in murine models of NMDAR antibody-associated pathology using rs-fMRI, finding impaired connectivity in hippocampal regions similar to human patients.

Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model

This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.

Brain Antibody Sequence Evaluation (BASE): an easy-to-use software for complete data analysis in single cell immunoglobulin cloning

BASE is a software tool for analyzing single-cell immunoglobulin cloning data, providing automated analysis with high accuracy and additional plasmid sequence confirmation.

State-dependent signatures of Anti-NMDA-Receptor Encephalitis: a dynamic functional connectivity study

This study uses dynamic functional connectivity analysis to identify state-dependent brain activity patterns in anti-NMDA receptor encephalitis, finding distinct differences from controls and strong predictive power.