Thomas C. Mettenleiter

The core herpes simplex-1 fusion complex drives cell-to-cell spreading of pathological Tau

This study shows HSV-1 fusion proteins enable cell-to-cell spread of pathological Tau, suggesting latent HSV-1 infection may contribute to neurodegenerative disease progression.

Spatiotemporal dynamics of alphaherpesviral latency and reactivation in the murine central nervous system

This study maps the spatiotemporal dynamics of alphaherpesviral latency and reactivation in the CNS using a modified PrV in mice, identifying key brain regions as viral reservoirs.

Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens

The knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

This study shows that knocking out the HMG domain of the porcine SRY gene causes sex reversal in pigs, leading to female genitalia in genetically male pigs.