Phosphoglycerate Kinase Can Adopt a Topologically Misfolded Form that is More Stable than its Native State
Yingzi Xia, Barbara T. Amann, Richard E. Gillilan, Yang Jiang, Piyoosh A. Sharma, Sreemantee Sen, Karen G. Fleming, Edward P. O’Brien, Stephen D. Fried
This study identifies a topologically misfolded form of E. coli phosphoglycerate kinase that is more stable than its native state and resists denaturation.
Journal of the American Chemical Society · Jan 6, 2026Peer-reviewedBiophysics