Author

Karen G. Fleming

Johns Hopkins UniversityORCID 0000-0001-5417-8830Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex KangiD· 1 shared Alyssa Q. StivingiD· 1 shared Anastassia Andreevna VorobievaiD· 1 shared Asim K. BeraiD· 1 shared Barbara T. Amann· 1 shared Binyong LiangiD· 1 shared Cameron M. ChowiD· 1 shared Dagan C. MarxiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperSynthetic Biology

Alex KangORCID

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3 papers

Recent·Most cited

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJan 6, 2026

Phosphoglycerate Kinase Can Adopt a Topologically Misfolded Form that is More Stable than its Native State

Yingzi Xia, Barbara T. Amann, Richard E. Gillilan…·Stephen D. Fried

This study identifies a topologically misfolded form of E. coli phosphoglycerate kinase that is more stable than its native state and resists denaturation.

2 citations

E. coliprotein structure

𝕏 PostBluesky

BiophysicsBiophysical JournalPeer-reviewedMay 21, 2024

The Molecular Basis for Hydrodynamic Properties of PEGylated Human Serum Albumin

Patrick J. Fleming, John J. Correia, Karen G. Fleming

The paper uses simulations and HullRad to predict hydrodynamic properties of PEGylated proteins, aiding in the design of modified therapeutics.

10 citations

protein structurestatistical model

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Synthetic BiologySciencePeer-reviewedFeb 19, 2021

De novo design of transmembrane beta-barrels

Anastassia Andreevna Vorobieva, Paul C. White, Binyong Liang…·David A. Baker

This study successfully designs transmembrane beta-barrels from first principles, revealing structural constraints and enabling custom pore design for biotechnology applications.

153 citationstop 1%

protein structureexperimental assay

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