Author

Piyoosh A. Sharma

Johns Hopkins UniversityORCID 0000-0002-1102-8602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Stephen D. FriediD· 2 shared Andrea A. PutnamiD· 1 shared Anirban DasiD· 1 shared Barbara T. Amann· 1 shared Chih-Yun Liu· 1 shared Cory J. BerklandiD· 1 shared Edward P. O’BrieniD· 1 shared Elise M. BrowniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Stephen D. FriedORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Phase separation of PGL-3 driven by structured domains that oligomerize and interact with terminal RGG motifs.

R. Kuroiwa, Piyoosh A. Sharma, Andrea A. Putnam, Stephen D. Fried, Géraldine Seydoux

This study identifies that structured domains in PGL-3 drive phase separation through oligomerization and interaction with RGG motifs, independent of RNA.

EMBO Reports · Mar 20, 2026Peer-reviewedBiophysics

Substituent-based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides

Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih-Yun Liu, Huan Gong, Jonathan L. Fascetti, Mark Gibson, Samuel T. Stealey, Silviya P. Zustiak, Cory J. Berkland, Piyoosh A. Sharma, Meredith E. Jackrel, Mark Andrew White, Jai S. Rudra

This study examines how substituents on benzyl groups affect self-assembly and immunogenicity of amphipathic peptides, showing that chemical modifications influence fibril formation and immune responses.

Advanced Science · Jan 20, 2026Peer-reviewedBioengineering

Phosphoglycerate Kinase Can Adopt a Topologically Misfolded Form that is More Stable than its Native State

Yingzi Xia, Barbara T. Amann, Richard E. Gillilan, Yang Jiang, Piyoosh A. Sharma, Sreemantee Sen, Karen G. Fleming, Edward P. O’Brien, Stephen D. Fried

This study identifies a topologically misfolded form of E. coli phosphoglycerate kinase that is more stable than its native state and resists denaturation.

Journal of the American Chemical Society · Jan 6, 2026Peer-reviewedBiophysics