STING causes replication stress and nascent DNA degradation via SAMHD1
Barbara Teodoro-Castro, Rafael Cançado de Faria, Elena V. Shashkova, Atika Malique, Madison B. Adolph, Lílian Nara David e Silva, Susana Gonzalo
This study shows STING causes replication stress and nascent DNA degradation via SAMHD1 in progeria and tumor cells, revealing a STING-SAMHD1 axis that drives genome instability.
bioRxiv · Mar 28, 2026 · PreprintCell Biology