Author

Lílian Nara David e Silva

Saint Louis UniversityORCID 0000-0002-2258-3038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Barbara Teodoro-Castro· 2 shared Elena V. ShashkovaiD· 2 shared Rafael Cançado de FariaiD· 2 shared Susana GonzaloiD· 2 shared Atika MaliqueiD· 1 shared Kyle S. McCommisiD· 1 shared Madison B. AdolphiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Barbara Teodoro-Castro

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 28, 2026

STING causes replication stress and nascent DNA degradation via SAMHD1

Barbara Teodoro-Castro, Rafael Cançado de Faria, Elena V. Shashkova…·Susana Gonzalo

This study shows STING causes replication stress and nascent DNA degradation via SAMHD1 in progeria and tumor cells, revealing a STING-SAMHD1 axis that drives genome instability.

1 citation

humanDNA methylation

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Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 10, 2025

A non-canonical cGAS-STING pathway drives cellular and organismal aging

Rafael Cançado de Faria, Lílian Nara David e Silva, Barbara Teodoro-Castro…·Susana Gonzalo

This study identifies a non-canonical cGAS-STING pathway that drives aging and progeria by promoting inflammation and senescence, and shows that targeting this pathway can improve aging-related phenotypes.

34 citationstop 1%

humanexperimental assay

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