Impaired perceptual learning in Fragile X syndrome is mediated by parvalbumin neuron dysfunction in V1 and is reversible.
Anubhuti Goel, Daniel A. Cantu, Janna L. Guilfoyle, Gunvant Chaudhari, Aditi Newadkar, Barbara Todisco, Diego de Alba, Nazim Kourdougli, Lauren Schmitt, Ernest V. Pedapati, Craig A. Erickson, Carlos Portera‐Cailliau
This study identifies parvalbumin neuron dysfunction in V1 as a mediator of impaired perceptual learning in Fragile X syndrome and shows that restoring PV neuron activity can reverse the deficit.
bioRxiv · Nov 13, 2017 · PreprintNeuroscience