Lauren Schmitt

Event-Related Spatio-Spectral Perturbation (ERSSP): A Scalp-Wide EEG Analysis Framework for Capturing Extralemniscal Thalamocortical Activity, Validated Using a Fragile X Syndrome Model

The paper introduces ERSSP, an EEG analysis framework to study extralemniscal thalamocortical activity, validated in Fragile X Syndrome showing increased spatial power increases.

Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity

This study investigates neural correlates of auditory hypersensitivity in FXS using EEG source analysis, finding frontal cortex hyperactivation and gamma desynchrony linked to auditory processing issues.

A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of Fmr1 KO mice and caused by loss of FMRP in cortical excitatory neurons

The paper identifies a shared electrophysiological biomarker of Fragile X Syndrome in human and mouse models, showing slowed alpha oscillations linked to FMRP loss in excitatory neurons.

An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m6A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

This study uses iPSC-derived neurons to show that FMRP deficiency in fragile X syndrome leads to m6A-mediated transcriptome dysregulation, causing synaptic dysfunction and suggesting therapeutic targets.

Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons.

The paper shows that FXS mice show impaired performance on distractor tasks, linked to reduced modulation of VIP interneurons.

Impaired perceptual learning in Fragile X syndrome is mediated by parvalbumin neuron dysfunction in V1 and is reversible.

This study identifies parvalbumin neuron dysfunction in V1 as a mediator of impaired perceptual learning in Fragile X syndrome and shows that restoring PV neuron activity can reverse the deficit.