This study shows that parvalbumin interneurons drive cortical network desynchronization and increased population activity dimensionality during development.

bioRxiv · Oct 23, 2026 · PreprintNeuroscience

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.

Anand Suresh, Nazim Kourdougli, Toshihiro Nomura, Jessie E. Buth, Soledad Miranda‐Rottmann, Carlos Andrés Sánchez-León, Michelle W. Wu, Sofia M. Nelson, Lauren T. Wall, Anne Tran, Roberto Araya, Anis Contractor, Michael J. Gandal, Carlos Portera‐Cailliau

Neuron · May 18, 2026Peer-reviewedNeuroscience

Improvement of sensory deficits in Fragile X mice by increasing cortical interneuron activity after the critical period

Nazim Kourdougli, Anand Suresh, Benjamin Liu, Pablo Juárez, A. Lin, David T. Chung, Anette Graven Sams, Michael J. Gandal, Verónica Martínez‐Cerdeño, Dean V. Buonomano, Benjamin J. Hall, Cédric Mombereau, Carlos Portera‐Cailliau

Neuron · Jul 13, 2023Peer-reviewedNeuroscience

EZcalcium: Open Source Toolbox for Analysis of Calcium Imaging Data

Daniel A. Cantu, Bo Wang, Michael W. Gongwer, Cynthia X. He, Anubhuti Goel, Anand Suresh, Nazim Kourdougli, Erica D. Arroyo, William Zeiger, Carlos Portera‐Cailliau

EZcalcium provides an open-source, GUI-based tool for analyzing calcium imaging data, integrating motion correction, segmentation, signal extraction, and deconvolution.

Frontiers in Neural Circuits · May 15, 2020Peer-reviewedNeuroscience

Impaired perceptual learning in Fragile X syndrome is mediated by parvalbumin neuron dysfunction in V1 and is reversible.

Anubhuti Goel, Daniel A. Cantu, Janna L. Guilfoyle, Gunvant Chaudhari, Aditi Newadkar, Barbara Todisco, Diego de Alba, Nazim Kourdougli, Lauren Schmitt, Ernest V. Pedapati, Craig A. Erickson, Carlos Portera‐Cailliau

This study identifies parvalbumin neuron dysfunction in V1 as a mediator of impaired perceptual learning in Fragile X syndrome and shows that restoring PV neuron activity can reverse the deficit.

bioRxiv · Nov 13, 2017 · PreprintNeuroscience