Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H
Swagata Konwar, Sophie Schroda, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, Jens Panse, Hong Wang, Robert Grosse, Manuel Rogg, Christoph Schell, Sabine Vidal‐y‐Sy, Xiaobo Liu, Christian Gorzelanny, Todor Tschongov, Karsten Häffner
This study identifies TSP-1 as a FH-independent inhibitor of the alternative complement pathway, showing its role in vasculitis by modulating complement activation and NETosis.
bioRxiv · Jul 31, 2024 · PreprintMolecular Biology