Manuel Rogg

Fibroblast-derived Collagen VI shapes the structure and function of the tumor-immune microenvironment in clear cell renal cell carcinoma

This study identifies collagen VI as a key ECM component in ccRCC stroma, showing its role in shaping tumor structure, function, and immune response, with implications for TKI therapy.

Mycobacterial infection uncovers plasticity of Kupffer cells

The paper investigates KC plasticity in mycobacterial infections, finding that KClow cells derived from bona fide KCs exhibit unique antimycobacterial activity and adaptability.

Proteomic characterization of sporadic clear cell renal cell carcinoma reveals a matrix-dense pseudocapsule and heterogeneous tumor subtypes

This study uses proteomics to characterize sporadic ccRCC, identifying a matrix-dense pseudocapsule and five tumor subtypes with distinct biological features.

Versatile roles of Annexin A4 in ccRCC: impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment

This study identifies ANXA4 as a key player in ccRCC, showing its role in membrane repair, transcriptional changes, and tumor microenvironment composition through genetic and computational analyses.

Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H

This study identifies TSP-1 as a FH-independent inhibitor of the alternative complement pathway, showing its role in vasculitis by modulating complement activation and NETosis.