Christian Gorzelanny

This study identifies two distinct carbohydrate-binding sites on CHI3L1, showing that chitin oligosaccharides and glycosaminoglycans bind to separate sites with different affinities and regulatory effects.

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.

The paper shows that extracellular vesicles bind to stretched von Willebrand factor, promoting platelet activation and aggregation, which can trap circulating tumor cells.

This study identifies TSP-1 as a FH-independent inhibitor of the alternative complement pathway, showing its role in vasculitis by modulating complement activation and NETosis.