Robert Grosse

Regulation of YAP activity by nuclear G-actin binding

This study identifies three high affinity G-actin binding sites in YAP and shows that actin binding is necessary for YAP's transcriptional activity and function.

TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing

This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.

The bat Influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment

This study shows that bat influenza A virus H18N11 attaches to MHCII clusters on host cells, causing local clustering of MHCII molecules similar to immunological synapse formation.

SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II

The paper shows calcium triggers nuclear actin assembly via SUN2, which clusters RNA polymerase II.

Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H

This study identifies TSP-1 as a FH-independent inhibitor of the alternative complement pathway, showing its role in vasculitis by modulating complement activation and NETosis.

Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells

This study identifies the Arp2/3 complex as critical for maintaining mast cell survival and tissue residency through actin-dependent mechano-protection.