JAK inhibition decreases the autoimmune burden in Down syndrome
Angela L. Rachubinski, Elizabeth B. Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Keith P. Smith, Paula Araya, Katherine A. Waugh, Ross E. Granrath, Eleanor C. Britton, Hannah R. Lyford, Micah G. Donovan, Neetha Paul Eduthan, Amanda A. Hill, Barry Martin, , Joaquin Maximiliano Espinosa
This study investigates immune dysregulation in Down syndrome and shows that JAK inhibition with tofacitinib reduces autoimmune symptoms and inflammatory markers without significant adverse effects.
eLife · Dec 31, 2024Peer-reviewedGenetic & Genomic Medicine