Author

Eleanor C. Britton

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Angela L. RachubinskiiD· 3 shared Joaquin Maximiliano EspinosaiD· 3 shared Kelly D. SullivaniD· 3 shared Matthew D. GalbraithiD· 3 shared Neetha Paul EduthaniD· 3 shared Belinda A Enriquez Estrada· 2 shared Hannah R. LyfordiD· 2 shared Katherine A. WaughiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

Angela L. RachubinskiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization

Micah G. Donovan, Neetha Paul Eduthan, Brian F. Niemeyer, Elena Woods, Eric Hoffmeyer, Natália Jaeger, Eleanor C. Britton, Bartosz J. Grzywacz, Joseph J. Fernandez, Galileo S. Dumont, Brian William Herrmann, Norman R. Friedman, Dallas Jones, Zdeněk Andrysík, Angela L. Rachubinski, , Joaquin Maximiliano Espinosa

This study identifies hyperactive interferon signaling and lymphoid tissue disorganization as drivers of adaptive immune dysfunction in Down syndrome across development and aging.

bioRxiv · Aug 4, 2026 · PreprintImmunology

JAK inhibition decreases the autoimmune burden in Down syndrome

Angela L. Rachubinski, Elizabeth B. Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Keith P. Smith, Paula Araya, Katherine A. Waugh, Ross E. Granrath, Eleanor C. Britton, Hannah R. Lyford, Micah G. Donovan, Neetha Paul Eduthan, Amanda A. Hill, Barry Martin, , Joaquin Maximiliano Espinosa

This study investigates immune dysregulation in Down syndrome and shows that JAK inhibition with tofacitinib reduces autoimmune symptoms and inflammatory markers without significant adverse effects.

eLife · Dec 31, 2024Peer-reviewedGenetic & Genomic Medicine

Interferon receptor gene dosage determines multiple hallmarks of Down syndrome

Katherine A. Waugh, Ross Minter, Jessica A Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha Paul Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdeněk Andrysík, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael P. Ludwig, Kyndal A. Schade, Dayna Tracy, , Joaquin Maximiliano Espinosa

The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.

bioRxiv · Feb 3, 2022 · PreprintGenetics