Chiral Histidine-Modified Gold Nanoclusters Loaded into Cationic Lipid Nanoparticles for Treatment of Biofilm-associated Infections
Zijian Ye, Xin Jin, Arnold C. Koekman, Mies J. van Steenbergen, Yi Liu, Zhentao Xing, Cornelis W. Seinen, Azin Khodaei, Enrico Mastrobattista, Joost P. G. Sluijter, Harrie Weinans, Raymond Michel Schiffelers, Jaqueline Lourdes Rios, Bart van der Wal, Zhiyong Lei
This paper develops chiral histidine-modified gold nanoclusters encapsulated in cationic lipid nanoparticles to treat biofilm-associated infections, showing enhanced efficacy in reducing bacterial burden and biomass.
bioRxiv · Mar 10, 2026 · PreprintMicrobiology