Enrico Mastrobattista

UDIST: unsupervised disentanglement of shape and texture for multi-scale phenotypic profiling in 2D microscopy

UDIST separates shape and texture in microscopy images into independent latent subspaces, enabling unbiased phenotypic analysis across biological scales.

Chiral Histidine-Modified Gold Nanoclusters Loaded into Cationic Lipid Nanoparticles for Treatment of Biofilm-associated Infections

This paper develops chiral histidine-modified gold nanoclusters encapsulated in cationic lipid nanoparticles to treat biofilm-associated infections, showing enhanced efficacy in reducing bacterial burden and biomass.

Detailed splenic single-cell biodistribution of phosphatidylglycerol-containing liposomes

This study compares the biodistribution of rigid and flexible liposomes in the spleen and identifies APC subsets involved in immune tolerance.

Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells

The paper identifies VHH/single-domain antibodies that either block or enhance Siglec-1 ligand binding to sialylated pathogens on dendritic cells.

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic Chip

This paper develops a 3D microfluidic chip model of the neurovascular unit that supports neural-vascular interactions and is used to study neuroinflammation and drug transcytosis.